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KMID : 0191120230380160127
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Journal of Korean Medical Science
2023 Volume.38 No. 16 p.127 ~ p.127
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Twenty-Five Year Trend Change in the Etiology of Pediatric Invasive Bacterial Infections in Korea, 1996?2020
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Song Seung-Ha
Lee Hyun-Ju
Lee Hoan-Jong
Song Eun-Song
Ahn Jong-Gyun
Park Su-Eun
Lee Taek-Jin
Cho Hye-Kyung
Lee Ji-Na
Kim Yae-Jean
Jo Dae-Sun
Seo Young-Beom
Kang Hyun-Mi
Lee Joon-Kee
Kim Chun-Soo
Ali Vafaei
Kim Hwang-Min
Choi Jae-Hong
Eun Byung-Wook
Kim Nam-Hee
Cho Eun-Young
Kim Yun-Kyung
Oh Chi-Eun
Kim Kyung-Hyo
Ma Sang-Hyuk
Jung Hyun-Joo
Lee Kun-Song
Kim Kwang-Nam
Choi Eun-Hwa
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Abstract
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Background : The coronavirus disease-2019 (COVID-19) pandemic has contributed to the change in the epidemiology of many infectious diseases. This study aimed to establish the pre-pandemic epidemiology of pediatric invasive bacterial infection (IBI).
Methods : A retrospective multicenter-based surveillance for pediatric IBIs has been maintained from 1996 to 2020 in Korea. IBIs caused by eight bacteria (Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pyogenes, Listeria monocytogenes, and Salmonella species) in immunocompetent children > 3 months of age were collected at 29 centers. The annual trend in the proportion of IBIs by each pathogen was analyzed.
Results : A total of 2,195 episodes were identified during the 25-year period between 1996 and 2020. S. pneumoniae (42.4%), S. aureus (22.1%), and Salmonella species (21.0%) were common in children 3 to 59 months of age. In children ≥ 5 years of age, S. aureus (58.1%), followed by Salmonella species (14.8%) and S. pneumoniae (12.2%) were common. Excluding the year 2020, there was a trend toward a decrease in the relative proportions of S. pneumoniae (rs = ?0.430, P = 0.036), H. influenzae (rs = ?0.922, P < 0.001), while trend toward an increase in the relative proportion of S. aureus (rs = 0.850, P < 0.001), S. agalactiae (rs = 0.615, P = 0.001), and S. pyogenes (rs = 0.554, P = 0.005).
Conclusion : In the proportion of IBIs over a 24-year period between 1996 and 2019, we observed a decreasing trend for S. pneumoniae and H. influenzae and an increasing trend for S. aureus, S. agalactiae, and S. pyogenes in children > 3 months of age. These findings can be used as the baseline data to navigate the trend in the epidemiology of pediatric IBI in the post COVID-19 era.
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KEYWORD
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Invasive Bacterial infections, Epidemiology, COVID-19, Children
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